He is driven by a desire for revenge on Mercer. James manages to escape to the near destruction of New York by the virus. The corporation, whose forces created the virus, captivates the main character and puts experiments on him. The new main character is the American military James Heller, in an attempt to stop the culprit of the epidemic, he himself becomes infected and receives Mercer's powers. It seemed that the city was saved, but a year later Mercer returns and causes another outbreak of the epidemic. Mercer along with the epidemic of the virus that turns people into mutants disappear. The unchanging studio Radical Entertainment worked on its development.
It is a direct plot continuation of the original game. Prototype 2 is a computer video game in the action genre.